Three incretins, compared on the record.

Figures from different trials are not a head-to-head comparison: the populations, durations and estimands differ. The head-to-head trials among these compounds are SURMOUNT-5, tirzepatide against semaglutide, completed, and TRIUMPH-5, retatrutide against tirzepatide, still running.

Primara Labs sells some of the compounds covered here. Every figure on this page links to its source and the date it was checked.

Comparisons

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Retatrutide vs tirzepatide
TRIUMPH-1 and SURMOUNT-1; head to head: TRIUMPH-5
Tirzepatide vs semaglutide
SURMOUNT-1 and STEP 1; head to head: SURMOUNT-5
Retatrutide vs semaglutide
TRIUMPH-1 and STEP 1; no head-to-head trial